學歷
1995-1997 英國倫敦大學博士
1967-1968 美國耶魯大學醫學院碩士
1959-1966 國立臺灣大學醫學院醫學士
1953-1959 高雄中學初高中
住院醫師訓練與研究
1971-1973 美國國家衛生研究院獎助愛荷華大學之血液與腫瘤研究
1970-1971 美國愛荷華大學住院醫師
1969-1970 美國華盛頓大學Barnes醫院婦產科住院醫師及密蘇里州聖路易 St. Lukes醫院住院醫師
1968-1969 美國康乃狄克州Bridgeport醫院實習醫師
教學經歷
1997-2006 美國德州大學M.D. Anderson癌症中心癌症血液及骨髓移植部兼任教授 、教授
2001-2006 美國德州大學休士頓健康科學中心布朗預防分子醫學研究所副所長
1997-1999 中央研究院生物醫學科學研究所特聘研究員及所長
1992-2006 美國德州大學休士頓健康科學中心Roy M. and Phyllis Gough Huffington講座教授
1991-1992 英國St. Bartholomew's醫學院William Harvey研究所客座教授
1983-2006 美國德州大學醫學院教授及血液腫瘤科主任、臨床研究中心主任、血管生物研究中心主任 、醫學院醫學系副系主任
1984-2006 美國德州Rice大學生物醫學研究實驗室兼任教授
1976-1983 美國芝加哥Rush 醫學院血液凝固與血栓部主任
1973-1976 美國愛荷華大學研究學者、助理教授
醫師經歷
1997-2006 美國德州休士頓M.D. Anderson癌症中心
1989-2006 美國德州休士頓Lyndon B. Johnson綜合醫院
1983-2006 美國德州休士頓Hermann紀念醫院
1976-1983 美國芝加哥Rush-Presbyterian-St. Luke's醫學中心
1973-1976 美國愛荷華大學附設醫院與愛荷華市榮民醫院
榮譽與傑出成就
2004 榮登美國Thomson ISI近十年學術論文被引用前十名作者
2000 獲頒美國德州大學休士頓健康科學中心院長學者獎
1997 獲選為美國醫師學會( American Association of Physicians, AAP )會員
1997 獲頒國際血栓學會SANOFI Prize
1994 獲得美國休士頓 Lanier市長頒佈12月9日為伍焜玉醫師日
1994 獲選為中央研究院院士
1985 獲頒台灣大學醫學院第四十屆傑出校友獎
1982 獲選為美國臨床研究學會(American Society of Clinical Investigation, ASCI) 會員
學術期刊編輯委員
2004-Present 編輯委員, Current Cardiology Review
2003-Present 副總編輯, Prostaglandins and Other Lipid Mediators
2001-Present 編輯委員, Arteriosclerosis, Thrombosis and Vascular Biology
1996-2004 副總編輯, Circulation
1994-2002 編輯委員, Tissue Engineering
1993-1995 編輯委員, Circulation
1986-1991 編輯委員, Prostaglandins
1987-1990 編輯委員, Eicosanoids
研究方向
Mediators of Arterial Thrombosis
Molecular Biology and Biochemistry of Cyclooxygenase and Nitric Oxide Synthase
著作
主要期刊論文(自1991年)
1 Deng, W.G., Tang, S.T., Tseng, H.P., Wu, K.K. Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding. Blood. 2006 Apr 11; [Epub ahead of print]
2 Liou, J.Y., Lee, S., Ghelani, D., Matijevic-Aleksic, N., Wu, K.K. Protection of endothelial survival by peroxisome proliferator-activated receptor-{delta} mediated 14-3-3 upregulation. Arterioscler. Thromb. Vasc. Biol. 2006 Apr 27; [Epub ahead of print]
3 Lin, T.N., Cheung, W.M., Wu, J.S., Chen, J.J., Lin, H., Chen, J.J., Liou, J.Y., Shyue, S.K., Wu, K.K. 15d-Prostaglandin J2 Protects Brain From Ischemia-Reperfusion Injury. Arterioscler. Thromb. Vasc. Biol. 26:481-487, 2006.
4 Liou, J.Y., Aleksic, N., Chen, S.F., Han, T.J., Shyue, S.K., Wu, K.K. Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance. Exp. Cell Res. 306:75-84, 2005.
5 Cieslik, K., Zhu, Y., Shtivelband, M., Wu, K.K. Inhibition of p90 ribosomal S6 kinase-mediated C/EBPbeta activation and COX-2 expression by salicylate. J. Biol. Chem., 280: 18411-18417, 2005.
6 Gibson, L.L., Hahner, L., Osborne-Lawrence, S., German, Z., Wu, K.K., Chambliss, K.L., Shaul, P.W. Molecular basis of estrogen-induced cyclooxygenase type 1 upregulation in endothelial cells. Circ. Res., 96: 518-525, 2005.
7 Huang, J-C., Wun, W-S.A., Goldsby, J.S., Matijevic-Aleksic, N., Wu, K.K. Cyclooxygenase-2-derived endogenous prostacyclin enhances mouse embryo hatching. Hum. Reprod. 19:2900-2906, 2004.
8 Huang, J-C., Goldsby, J.S., Arbab, F., Melhem, Z., Aleksic, N., Wu, K.K. Oviduct prostacyclin functions as a paracrine factor to augment the development of embryos. Hum. Reprod. 19: 2907-2912, 2004.
9 Yu, I-S., Lin, S-R., Huang, C-C., Tseng, H-Y., Huang, P-H., Shi, G-Y., Wu, H-L., Tang, C-L., Chu, P-H., Wang, L-H., Wu, K.K., Lin, S-W. TXAS-deleted mice exhibit normal thrombopoiesis, defective hemostasis and resistance to arachidonate-induced death. Blood, 104: 135-142, 2004.
10 Deng, W-G., Zhu, Y., Wu, K.K. Role of p300 and PCAF in regulating cyclooxygenase-2 promoter activation by inflammatory mediators. Blood, 103: 2135-2142, 2004.
11 Afshar-Kharghan, V., Matijevic-Aleksic, N., Ahn, C., Boerwinkle, E., Wu, K.K., Lopez, J.A. The variable number of tandem repeat polymorphism of platelet glycoprotein Ibα and risk of coronary heart disease. Blood, 103: 963-965, 2004.
12 Delgado, R.M. 3rd, Nawar, M.A., Zewail, A.M., Kar, B., Vaughn, W.K., Wu, K.K., Aleksic, N., Sivasubramanian, N., McKay, K., Mann, D.L., Willerson, J.T. Cyclooxygenase-2 inhibitor treatment improves left ventricular function and mortality in a murine model of doxorubicin-induced heart failure. Circulation, 109: 1428-1433, 2004.
13 Deng, W-G., Zhu, Y., Montero, A., Wu, K.K. Quantitative analysis of binding of transcription factor complex to biotinylated DNA probe by a streptavidin-agarose pulldown assay. Anal. Biochem. 323: 12-18, 2003.
14 Deng, W-G., Wu, K.K. Regulation of inducible nitric oxide synthase expression by p300 and p50 acetylation. J. Immunology, 171: 6581-6588, 2003.
15 Huang, J.C., Wun, W.S.A., Goldsby, J.S., Wun, I.C., Falconi, S.M., Wu, K.K. Prostacyclin enhances embryo hatching but not sperm motility. Hum. Reprod., 18: 2582-2589, 2003.
16 Wu, K.K., Aleksic, N., Ballantyne, C.M., Ahn, C., Juneja, H., Boerwinkle, E. Interaction between soluble thrombomodulin and intercellular adhesion molecule-1 in predicting risk of coronary heart disease. Circulation, 107:1729-1732, 2003.
17 Chen, P-F., Berka, V., Wu, K.K. Differential effects of mutations in human endothelial nitric oxide synthase at residues Tyr-357 and Arg-365 on L-arginine hydroxylation and GN-hydroxy-L-arginine oxidation. Arch. Biochem. Biophys., 411: 83-92, 2003.
18 Deng, W-G., Zhu, Y., Wu, K.K. Upregulation of p300 binding and p50 acetylation in tumor necrosis factor-α induced cyclooxygenase-2 promoter activation.J. Biol. Chem., 278: 4770-4777, 2003.
19 Cieslik, K., Zhu, Y., Wu, K.K.Salicylate suppresses macrophage nitric oxide synthase-2 and cyclooxygenase-2 expression by inhibiting C/EBPβ-binding via a common signaling pathway. J. Biol. Chem., 277: 49304-49310, 2002.
20 Huang, J.C., Arbab, F., Tumbusch, K.J., Goldsby, J.S., Matijevic-Aleksic, N., Wu, K.K. Human Fallopian Tubes Express Prostacyclin (PGI) Synthase and Cyclooxygenases and Synthesize Abundant PGI. J. Clin. Endocrinol. Metab., 87: 4361-4368, 2002.
21 Deng, W., Saunders, M.A., Gilroy, D.W., He, X-Z., Yeh, H., Zhu, Y., Shtivelband, M.I., Ruan, K-H., Wu, K.K. Purification and characterization of a cyclooxygenase-2 and angiogenesis suppressing factor produced by human fibroblasts. FASEB J., 16: 1286-1288, 2002.
22 Schroer, K., Zhu, Y., Saunders, M.A., Deng, W-G., Xu, X-M., Meyer-Kirchrath, J., Wu, K.K. The obligatory role of cyclic AMP response element in cyclooxygenase-2 promoter induction and feedback regulation by inflammatory mediators. Circulation, 105: 2760-2765, 2002.
23 Scott, B.T., Hasstedt, S.J., Bovill, E.G., Callas, P.W., Valliere, J.E., Wang, L., Wu, K.K., Long, G.L. Characterization of the human prostaglandin H synthase 1 gene (PTGS1): exclusion by genetic linkage analysis as a second modifier gene in familial thrombosis. Blood Coagulation and Fibrinolysis, 13: 519-531, 2002.
24 Lin, H., Lin, T-N., Cheung, W-M., Nian, G-M., Tseng, P-H., Chen, S-F., Chen, J-J., Shyue, S?K., Liou, J-Y., Wu, C-W., Wu, K.K. Cyclooxygenase-1 (COX-1) and bicistronic COX-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction. Circulation, 105: 1962-1969, 2002.
25 Zhu, Y., Saunders, M.A., Yeh, H., Deng, W-G., Wu, K.K. Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer binding proteins. J. Biol. Chem., 277: 6923-6928, 2002.
26 Deng, W-G., Ruan, K-H., Du, M., Saunders, M.A., Wu, K.K. Aspirin and salicylate bind to immunoglobulin heavy chain binding protein (BiP) and inhibits its ATPase activity in human fibroblasts. FASEB J., 15: 2463-2470, 2001.
27 Juan, S-H., Lee, T-S., Tseng, K-W., Liou, J-Y., Shyue, S-K., Wu, K.K., Chau, L-Y. Adenovirus-mediated heme oxygenase-1 gene transfer inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. Circulation, 104: 1519-1525, 2001.
28 Liou, J.Y., Deng, W.G., Gilroy, D.W., Shyue, S.K., Wu, K.K. Colocalization and Interaction of Cyclooxygenase-2 with Caveolin-1 in Human Fibroblasts. J. Biol. Chem., 276: 34975-34982, 2001.
29 Gilroy, D.W., Saunders, M.A., Wu, K.K. COX-2 expression and cell cycle progression in human fibroblasts. Am. J. Physiol. Cell Physiol., 281: C188-194, 2001.
30 Saunders, M.A., Sansores-Garcia, L., Gilroy, D.W., Wu, K.K. Selective suppression of CCAAT/enhancer-binding protein beta binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts. J. Biol. Chem., 276: 18897-18904, 2001.
31 Shyue, S.K., Tsai, M.J., Liou, J.Y., Willerson, J.T., Wu, K.K. Selective Augmentation of Prostacyclin Production by Combined Prostacyclin Synthase and Cyclooxygenase-1 Gene Transfer. Circulation, 103: 2090-2095, 2001.
32 Cieslik, K., Abrams, C.S., Wu, K.K. Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma/Janus kinase 2/MEK-1-dependent pathway. J. Biol. Chem., 276: 1211-1219, 2001.
33 Gilroy, D.W., Saunders, M.A., Sansores-Garcia, L., Matijevic-Aleksic, N., Wu, K.K. Cell cycle-dependent expression of cyclooxygenase-2 in human fibroblasts. FASEB J. 15: 288-290, 2001.
34 Gilroy, D.W., Saunders, M.A., Wu, K.K. COX-2 expression and cell-cycle progression in human fibroblasts. Am. J. Physiol. Cell Physiol. 281:C188-C194, 2001.
35 Wu, K.K., Aleksic, N., Ahn, C., Boerwinkle, E., Folsom, A.R., Juneja, H.S. Thrombomodulin ALA 455 VAL polymorphism and risk of coronary heart disease. Circulation, 103: 1386-1389, 2001.
36 McCormick, S.M., Whitson, P.A., Wu, K.K., McIntire, L.V. Shear stress differentially regulates PGHS-1 and PGHS-2 protein levels in human endothelial cells. Ann. Biomed. Eng., 28: 824-833, 2000.
37 Aleksic, N., Juneja, H., Folsom, A.R., Ahn, C., Boerwinkle, E., Chambless, L.E., Wu, K.K. Platelet PLA2 allele and incidence of coronary heart disease: results from the Atherosclerosis Risk In Communities (ARIC) Study. Circulation, 102: 1901-1905, 2000.
38 Liou, J-Y. Shyue, S-K., Tsai, M.J., Chung, C.L., Chu, K.Y., Wu, K.K. Colocalization of prostacyclin synthase with prostaglandin H synthase-1 (PGHS-1) but not phorbol ester-induced PGHS-2 in cultured endothelial cells. J. Biol. Chem., 275: 15314-15320, 2000.
39 Chen, P-F., Wu, K.K. Characterization of the roles of the 594-645 region in human endothelial nitric-oxide synthase in regulating calmodulin binding and electron transfer. J. Biol. Chem., 275: 13155-13163, 2000.
40 Cieslik, K., Lee, C-M., Tang, J-L., Wu, K.K. Transcriptional regulation of endothelial nitric-oxide synthase by an interaction between casein kinase 2 and protein phosphatase 2A. J. Biol. Chem., 274: 34669-34675, 1999.
41 Godbey, W.T., Wu, K.K., Hirasaki, G.J., Mikos, A.G. Improved packing of poly(ethyleninmine)/DNA complexes increases transfection efficiency. Gene Therapy, 6: 1380-1388, 1999.
42 Folsom, A.R., Rosamond, W.D., Shahar, E., Cooper, L.S., Aleksic, N., Nieto, F.J., Rasmussen, M.L., Wu, K.K. Prospective study of markers of hemostatic function with risk of ischemic stroke. Circulation, 100: 736-742, 1999.
43 Salomaa, V., Matei, C., Aleksic, N., Sansores, L., Folsom, A.R., Juneja, H., Chambless, L.E., Wu, K.K. Soluble thrombomodulin as a predictor of incident coronary heart disease: The ARIC Study. Lancet, 353: 1729-1734, 1999.
44 Xu, X-M., Sansores-Garcia, L., Chen, X-M., Matijevic-Aleksic, N., Du, M., Wu, K.K. Suppression of inducible cyclooxygenase-2 gene transcription by aspirin and sodium salicylate. Proc. Natl. Acad. Sci. USA, 96: 5292-5297, 1999.
45 Godbey, W.T., Wu, K.K., Mikos, A.G. Tracking the intracellular path of poly (ethylenimine)/DNA complexes for gene delivery. Proc. Natl. Acad. Sci. USA, 96: 5177-5181, 1999.
46 Godbey, W.T., Wu, K.K., Mikos, A.G. Size matters: Molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle. J. Biomed. Mat. Res., 45: 268-275, 1999.
47 Chen, P-F., Berka, V., Tsai, A-L. and Wu, K.K. Effects of D369 and R372 mutations on heme environment and function in human endothelial nitric oxide synthase. J. Biol. Chem., 273: 34164-34170, 1998.
48 Du, M., Sansores-Garcia, L., Zu, Z. and Wu, K.K. Cloning and expression analysis of a novel salicylate suppressible gene, Hs-CUL-3, a member of Cullin/Cdc53 family. J. Biol. Chem., 273: 24289-24292, 1998.
49 Cieslik, K., Zembowicz, A., Tang, J_L. and Wu, K.K. Transcriptional regulation of endothelial nitric oxide synthase by lysophosphatidylcholine. J. Biol. Chem., 273: 14885-14890, 1998.
50 Chen, P-F., Tsai, A-L., Berka, V., and Wu, K.K. Mutation of Glu-361 in human endothelial nitric oxide synthase selectively abolishes L-arginine binding without perturbing the behavior of heme and other redox centers. J. Biol. Chem., 272: 6114-6118, 1997.
51 Xu, X-M., Tang, J-L., Chen, X., Wang, L-H., Wu, K.K. Involvement of two Sp1 elements in basal endothelial prostaglandin H synthase-1 promoter activity. J. Biol. Chem., 272: 6943-6950, 1997.
52 Shyue, S-K., Ruan, K-H., Wang, L-H., and Wu, K.K. Prostacyclin synthase active sites: identification by molecular modeling-guided site-directed mutagenesis. J. Biol. Chem., 272: 3657-3662, 1997.
53 Tazawa, R., Green, E.D., Ohashi, K., Wu, K.K., and Wang, L-H. Characterization of the complete genomic structure of human thromboxane synthase gene and functional analysis of its promoter. Arch. Biochem. and Biophys., 334, 2: 349-356, 1996.
54 Wang, L.-H., Matijevic-Aleksic, N., Hsu, P.-Y., Ruan, K.-H., Wu, K.K., and Kulmacz, R.J.. Identification of thromboxane A2 synthase active site residues by molecular modeling-guided site-directed mutagenesis. J. Biol. Chem., 271: 19970-19975, 1996.
55 Chen, P.-F., Tsai, A.-L., Vladimir, B., and Wu, K.K. Endothelial nitric-oxide synthase. Evidence for bidomain structure and successful reconstitution of catalytic activity from two separate domains generated by a baculovirus expression system. J. Biol. Chem., 271: 14631-14635, 1996.
56 Zoldhelyi, P., McNatt, J., Xu, X-M., Loose-Mitchell, D., Meidell, R.S., Clubb, F.J., Buja, L.M., Willerson, J.T.,. Wu, K.K. Prevention of arterial thrombosis by adenovirus-mediated transfer of cyclooxygenase gene. Circulation, 93: 10-17, 1996.
57 Shahar, E., Folsom, A.R., Salomaa, V.V., Stinson, V.L., McGovern, P.G., Shimakawa, T., Chambless, L.E., Wu, K.K. Relation of hormone-replacement therapy to measures of plasma fibrinolytic activity. Circulation, 93: 1970-1975, 1996.
58 Chen, P-F., Tsai, A-L., Wu, K.K. Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity. Biochem. Biophys. Res. Commu., 215: 1119-1129, 1995.
59 Tang, J-L., Zembowicz, A., Xu, X-M., and Wu, K.K. Role of Sp1 in transcriptional activation of human nitric oxide synthase type III gene. Biochem. Biophys. Res. Commu., 213: 673-680, 1995.
60 Zembowicz, A., Jones, S.L., and Wu, K.K. Induction of cyclooxygenase-2 in human umbilical vein endothelial cells by lysophosphatidylcholine. J. Clin. Invest., 96: 1688-1692, 1995.
61 Zembowicz, A., Tang, J-L., and Wu, K.K. Transcriptional induction of endothelial nitric oxide synthase type-III by lysophosphatidylcholine. J. Biol. Chem., 270: 17006-17010, 1995.
62 Salomaa, V., Stinson, V., Kark, J.D., Folsom, A.R., Davis, C.E., Wu, K.K. Association of fibrinolytic parameters with early atherosclerosis. The ARIC Study. Atherosclerosis Risk in Communities Study. Circulation, 91: 284-290, 1995.
63 Chen, P-F, Tsai, A-L and Wu, K.K. Cysteine 184 of endothelial nitric oxide synthase is involved in heme coordination and catalytic activity. J. Biol. Chem., 269: 25062-25066, 1994.
64 Sanduja, S.K., Tsai, A-L, Matijevic-Aleksic, N. and Wu, K.K. Kinetics of prostacyclin synthesis in PGHS-1-overexpressed endothelial cell. Am. J. Physiol., 267: C1459-C1466, 1994.
65 Pereira, B., Wu, K.K. and Wang, L-H. Molecular cloning and characterization of bovine prostacyclin synthase. Biochem. Biophys. Res. Comm., 203: 59-66, 1994.
66 Tazawa, R., Xu, X-M, Wu, K.K. and Wang L-H. Characterization of the genomic structure, chromosomal location and promoter of human prostaglandin H synthase-2 gene. Biochem. Biophys. Res. Comm., 203: 190-199, 1994.
67 Ruan, K-H, Li, P., Kulmacz, R.J. and Wu, K.K. Characterization of the structure and membrane interaction of NH2-terminal domain of thromboxane A2 synthase. J. Biol. Chem., 269: 20938-20942, 1994.
68 Ruan, K-H, Wang, L-H, Wu, K.K. and Kulmacz, R.J. Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum. J. Biol. Chem., 268: 19483-19490, 1993.
69 Xu, X-M, Ohashi, K., Sanduja, S.K., Ruan, K-H, Wang, L-H and Wu, K.K. Enhanced prostacyclin synthesis in endothelial cells by retrovirus-mediated transfer of prostaglandin H synthase cDNA. J. Clin. Invest., 91: 1843-1849, 1993.
70 Wang, L-H, Hajibeigi, A., Xu, X-M, Loose-Mitchell, D. and Wu, K.K. Characterization of the promoter of human prostaglandin H synthase-1 gene. Biochem. Biophys. Res. Comm., 190: 406-411, 1993.
71 Pereira, B., Wu, K.K. and Wang, L-H. Bovine prostacyclin synthase: purification and isolation of partial cDNA. Biochem. Biophys. Res. Comm., 197: 1041-1048, 1993.
72 Ohashi, K., Ruan, K-H, Kulmacz, R.J., Wu, K.K. and Wang, L-H. Primary structure of human thromboxane synthase determined from the cDNA sequence. J. Biol. Chem., 267: 789-793, 1992.
73 Wu, K.K., Sanduja, R., Tsai, Ah-lim, and Loose-Mitchell, D.: Aspirin inhibits the de novo synthesis and the mRNA level of prostaglandin H synthase in cultured endothelial cells. Proc. Natl. Acad. Sci. USA, 88: 2384-2387, 1991.
74 Wang, L-H, Ohashi, K., and Wu, K.K.: Isolation of partial complementary DNA encoding human thromboxane synthase. Biochem. Biophys. Res. Comm., 177: 286-291, 1991.
主要受邀評論文章與書籍章節(自1988年)
1 Wu, K.K. Analysis of Protein-DNA binding by Streptavidin-Agarose Pulldown. In: Methods in Molecular Biology, vol. 338: Gene Mapping, Discovery, and Expression: Methods and Protocols. M. Bina, Ed., Humana Press, Totowa, New Jersey, pp. 281-290, 2006.
2 Wu, K.K., Liou, J.Y. Cellular and molecular biology of prostacyclin synthase. 50th Anniversary of Oxygenases Special Issue Inveited Review. Biochem Biophys Res Commun., 338: 45-52, 2005.
3 Wu, K.K., Liou, J.Y., Cieslik, K. Transcriptional Control of COX-2 via C/EBPbeta. Arterioscler. Thromb. Vasc. Biol. 25:679-685, 2005.
4 Wu, K.K., Matijevic-Aleksic, N. Molecular aspects of thrombosis and antithrombotic drugs. Crit. Rev. Clin. Lab Sci. 42:249-277, 2005.
5 Wu, K.K. Novel mechanisms of aspirin pharmacologic actions: a model for studying herbal natural products. Thromb. Res. 117:61-67, 2005.
6 Wu, K.K., Willerson, J.T. Monitoring platelet function in glycoprotein IIb-IIIa inhibitor therapy. Circulation, Editorial, 103:2528-2530, 2001.
7 Wu, K.K. Aspirin and salicylate: an old remedy with a new twist. Circulation, Editorial, 102: 2022-2023, 2000.
8 Thiagarajan, P., and Wu, K.K. Mechanisms of Antithrombotic Drugs. In: Advances in Pharmacol., 46: 297-324, 1999.
9 Wu, K.K. Nitric Oxide Synthase Gene Regulation. In: The Pathophysiology and Clinical Applications of Nitric Oxide. G. Rubanyi, Ed., Harwood Academic Publishers, Amsterdam, The Netherlands, pp. 35-45, 1999.
10 Wu, K.K. Cyclooxygenase-2 induction in congestive heart failure: friend or foe? Circulation, Editorial, 98: 95-6, 1998.
11 Wickline, S., Wu, K., et al . “NHLBI/FDA conference on thrombosis and infections with cardiovascular devices. J. Biomed. Mat. Res., 42: 341-346, 1998.
12 Wu, K.K. “Cyclooxygenase gene expression and regulation.” In: Eicosanoids, Aspirin and Asthma, C. Lenfant, A. Szczeklik, R.J. Gryglewski and J.R. Vane, Eds., Marcel Dekker, Inc., New York, New York, pp. 129-144, 1998.
13 Wu, K.K. Biochemical Pharmacology of Nonsteroidal Anti-inflammatory Drugs. Biochem. Pharmacol., 55: 543-547, 1998.
14 Wu, K.K. Regulation and augmentation of prostacyclin and nitric oxide synthesis. J. Formosan Med. Assoc., 9: 661-666, 1996.
15 Wu, K.K., and Thiagarajan, P. Endothelial cell function in hemostasis and thrombosis. Annu. Rev. Med., 47: 315-331, 1996.
16 Wu, K.K. Inducible cyclooxygenase and nitric oxide synthase. Adv. Pharmacol., 33: 179-207, 1995.
17 Wu, K.K. Molecular Regulation and Augmentation of Prostacyclin Biosynthesis. Mediators in the Cardiovascular System: Regional Ischemia. Agents and Actions Supplements. K. Schror and C.R. Pace-Asciak, Eds. Birkhauser Verlag, Basel, Boston, Berlin, Vol. 45: 11-17, 1994.
18 D'Souza, D., Phillips, M., Hellums, J.D. and Wu, K.K. Platelet activation and arterial thrombosis. Lancet. 344: 991-995, 1994.
19 Wu, K.K. and Stinson, V. Laboratory evaluation of arterial thrombosis. Current Opinion in Hematology, 296-300, 1993.
20 Wu, K.K. Endothelial cell function in hemostasis and thrombosis. In: Endothelium in Health and Disease, S. Chien, Ed. Plenum Publishing, pp. 127-134, 1988.
專書
01. Wu, K.K. (editor): Pathophysiology and Management of Thromboembolic Disorders. PSG Publishing Company, Inc., Massachusetts, 1984.
02. Wu, K.K., and Rossi, E.C. (co-editors): Prostaglandins in Cardiovascular and Thrombotic Disorders. Year Book Medical Publishers, 1981.
